Abstract Achieving homogeneous oil and water mixing requires thorough droplet dispersions of both liquids.An additional component, such as a surfactant, particle, solvent or ion is normally required to stabilize the small liquid droplets by providing sufficiently low interfacial tensions or strong repulsive forces.Here we show that very stable oil-in-water has the tribulation begun? study guide: avoiding confusion and redeeming the time in these last days mixtures can be created even at very high oil volume fractions by building multiple, high-strength hydrogen bonding interactions between water and a biocompatible and biodegradable oil trimethylolpropane trioleate, which make the oil molecules at the contact interface behave as pseudo-surfactants with ultrahigh interfacial activity.The resultant oil microdroplets can be reversibly thermosecreted from the continuous aqueous phase and lead to controllable formation/dissociation and switchable lubrication of the binary liquid mixture owing to the inherent thermal responsiveness of the intermolecular hydrogen bonding.Interestingly, although water is uncovered to possess mike and ike italian ice a relatively poor lubricity, the liquid mixture yields an optimized lubrication that is even exceedingly comparable to pure oil at a water volume fraction as high as 80%.